IEM 66-2005-53

HIGHLY REACTIVE ELECTROGENERATED ZINC:
PREPARATION AND ITS USE IN CROSS-COUPLING REACTIONS

Highly reactive zinc metal was prepared by electrolysis of a N,N-dimethylformamide (DMF) solution containing naphthalene
and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This highly reactive
electrogenerated zinc (EGZn/Naph) was used for transformation of bromoalkanes into the corresponding organozinc
bromides, which can not be achieved by the use of usual zinc metals. Reaction of the organozinc compounds were thus
prepared with various aryl iodides in the presence of 5 mol% of palladium catalyst to give the corresponding cross-coupling
products in high yields. Arylzinc iodides were also prepared by the use of this highly reactive zinc, and they were reacted with
other iodides to give the corresponding cross-coupled biaryls in good yields.