MICMMAT 180-2013-235

Role of 3-aminopropyltriethoxysilane in the preparation of mesoporous
silica nanoparticles for ibuprofen delivery: Effect on physicochemical
properties

The development of mesoporous silica nanoparticle-based platforms for a controlled drug delivery was
studied. Mesoporous silica nanoparticles (MSN) was synthesized and modified with 3-aminopropyltriethoxysilane
(APTES) using co-condensation (MSNco) and post-grafting (MSNpost) methods. X-ray diffraction
(XRD) and transmission electron microscopy (TEM) data confirmed the formation of ordered
mesostructured silica nanoparticles. The performance of MSNs was then tested on an ibuprofen immobilization
and release. The results revealed that unmodified MSN demonstrated the best immobilization
rate and capacity of ibuprofen (98%), MSNpost exhibited higher ibuprofen adsorption (78%) as compared
to MSNco (71%), suggesting the modification method is not the dominant factor for the adsorption studied.
In fact, according to the FT-IR results, the silanol groups density was found to be the contributing factor
that affected the adsorption. The in vitro drug release was also investigated with simulated biological
fluids. In 20 h, MSNco showed the fastest release of ibuprofen (100%), followed by MSN (50%) and MSNpost
(38%). Both pore size and amine groups influenced the rate of the release process. From the results, MSN
and MSNpost is suggested to have suitable features for slow drug release which provides constant release
over a defined period to avoid repeated administration. While MSNco could be best employed as a fast
release system that provides initial burst of drug release to achieve rapid and maximum relief.